Frailty trajectories before and after diabetes: a prospective cohort study in the UK and the US
Incident diabetes is linked to faster frailty progression before and at diagnosis, whereas post-diagnosis trajectories diverged between the UK and US - showing continued acceleration in the UK but largely stable frailty in the US - with no overall evidence of further acceleration in pooled analyses. These findings indicate that diabetes diagnosis is a turning point in the frailty trajectory and highlight the need for stage- and context-specific prevention.
Authors
- Yifan Chen (ORCID: https://orcid.org/0000-0002-9373-5633)
- Zhangling Chen (ORCID: https://orcid.org/0000-0002-4995-8485)
- Zewei Chen (ORCID: https://orcid.org/0000-0001-7758-7581)
- Chenyang Li (ORCID: https://orcid.org/0000-0002-4930-5871)
- Xiaoqin Luo (ORCID: https://orcid.org/0009-0002-3907-1087)
- Jian Lin
- Murong Xie
- Y J Wu
Institutions
- Central South University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wenzhou Medical University (CN)
- Erasmus MC (NL)
- Second Xiangya Hospital of Central South University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1097/js9.0000000000004963
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00