Molecular and biochemical correlates of frontal lobe white matter degeneration in humans with alcohol use disorder
Human AUD anterior frontal lobe WM pathology is accompanied by significant alterations in oligodendrocyte and astrocyte function, with alterations in Notch and insulin/IGF signaling. The findings provide new information on the mechanisms of AUD-mediated WM degeneration as well as potential strategies for diagnosing ARBD in humans.
Authors
- Ming Tong
- Greg Sutherland
- Suzanne M. de la Monte
Institutions
- The University of Sydney (AU)
- Brown University (US)
Publication Details
- Journal
- Advances in Drug and Alcohol Research
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/adar.2026.15431
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health