Tertiary lymphoid structures correlate with reduced recurrence risk and enhanced antitumor immunity in esophageal squamous cell carcinoma with pathologic non-complete response to neoadjuvant chemoimmunotherapy
TLS status was the independent predictor of postoperative recurrence in non-pCR ESCC. TLS status correlated with the composition, functional state, and interaction patterns of immune cells. Specialized immune niches existed in non-pCR ESCC with TLS, potentially contributing to antitumor immune responses.
Authors
- Yang Wo (ORCID: https://orcid.org/0000-0002-8809-8860)
- Feng Qin Hou
- Zheyi Wang (ORCID: https://orcid.org/0000-0002-5016-3647)
- Wenjie Jiao (ORCID: https://orcid.org/0000-0002-2393-2324)
- Yihua Sun
- Yizhou Peng
- Xuxia Shen
- Xiongfei Li
- Tong Lu
- Zijiang Yang
Institutions
- Qingdao University (CN)
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Kunming Medical University (CN)
- Ruijin Hospital (CN)
- Shanghai Chest Hospital (CN)
- Fudan University Shanghai Cancer Center (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1186/s40164-026-00748-6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00