Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer
The results underscore the pivotal function of exosomal EPHA2 in mediating the transfer of metastatic potential among heterogeneous breast cancer cell populations. Targeting the EPHA2-TGF-βRI signaling axis may provide a novel therapeutic approach for preventing or limiting breast cancer metastasis.
Authors
- Yidi Jia
- Fei Zhang (ORCID: https://orcid.org/0000-0003-4533-6205)
- Hui Guo (ORCID: https://orcid.org/0009-0007-3483-0204)
- Luoming Zhang (ORCID: https://orcid.org/0000-0002-9007-0947)
- Liming Liu (ORCID: https://orcid.org/0009-0003-1691-670X)
- R. F. Niu (ORCID: https://orcid.org/0009-0001-6017-0699)
- Yueni Mo
- Wei Zhou
- Xiaoxue Li
- Yichu Zhang
- Lanlan Song
- Yanfen Cui
- He Zhang
- Zhiyong Wang
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2026-02-23
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0440
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00