Collagen-mediated pro-tumorigenic MAPK activation drives stromal-immune reprogramming in solid cancers
Our findings demonstrate that intratumoral collagen deposition is a key regulator of the TME in gastric cancer, promoting tumor progression through MAPK signaling pathway activation. These results demonstrate the promise of collagen as both a prognostic indicator and a therapeutic target, offering fresh perspectives on the underlying mechanisms of TME remodeling and tumor progression across various solid tumors.
Authors
- H. Helen Lin (ORCID: https://orcid.org/0009-0005-9709-0755)
- Junli Ding
- Huning Jiang
- Zeyu Wang (ORCID: https://orcid.org/0000-0001-7314-7888)
- Yun Cai
- Hanfang Fan
- T. Xia
- Haihua Zhou
- Yichao Zhu
- Liangfeng Xu
Institutions
- Jiangsu University (CN)
- Jintan People's Hospital (CN)
- Wuxi People's Hospital (CN)
- Jingning County People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fimmu.2026.1744126
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical University