Detection and characterization of Hepatitis B virus double-stranded linear DNA-derived covalently closed circular DNA in chronic hepatitis B patients
dsl-cccDNA is more abundant and diverse among the HBeAg(+) CHB subjects. The existence of replication-defective dsl-cccDNA may facilitate immune evasion and HBV integration, and complicate HBV pathogenesis.
Authors
- Fwu-Shan Shieh
- Hsin-Ni Liu
- Haitao Guo (ORCID: https://orcid.org/0000-0002-7146-916X)
- Marc G. Ghany
- Ning Sun
- ThiThuyTu Nguyen
- Elena Kim
- Zhili Wang
- Selena Y. Lin
- Yuanjie Liu
- Daryl T. Y. Lau
- Richard K. Sterling
- Ying-Hsiu Su
- Raymond T. Chung
Institutions
- National Institutes of Health (US)
- Beth Israel Deaconess Medical Center (US)
- Virginia Commonwealth University (US)
- Massachusetts General Hospital (US)
- JBS Science (United States) (US)
- UPMC Hillman Cancer Center (US)
- Baruch S. Blumberg Institute (US)
Publication Details
- Journal
- PLoS Pathogens
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1371/journal.ppat.1013999
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00