Respiratory Syncytial Virus After CAR T-cell Therapy: Risk Factors and Outcomes in a Multicenter Retrospective Cohort
Among 667 CAR-T recipients, the 2-year cumulative incidence of RSV was 7%, with 29% of diagnosed cases progressing to LRTI. Older age and lymphopenia were associated with severity. Most infections (74%) occurred beyond day +100 (median 8 months). No RSV-attributable deaths occurred. Clinical vigilance is warranted, especially during RSV season.
Authors
- Malin L. Hultcrantz (ORCID: https://orcid.org/0000-0002-9045-6495)
- Lia Palomba
- Jennifer Kimberly Lue (ORCID: https://orcid.org/0000-0001-8153-1820)
- Mika Geva (ORCID: https://orcid.org/0000-0003-3473-3272)
- Alexander P. Boardman (ORCID: https://orcid.org/0000-0001-7169-9275)
- Noriko Nishimura (ORCID: https://orcid.org/0000-0001-8720-6930)
- S. Z. Usmani
- Sigrun Einarsdottir (ORCID: https://orcid.org/0000-0003-4756-6805)
- G. L. Shah
- Hazim Khatib (ORCID: https://orcid.org/0000-0002-7083-5113)
- Kayleen Shi
- Zainab Shahid (ORCID: https://orcid.org/0000-0002-0716-8338)
- Jabour Halloun
- Niveen Shibli
- Susan K. Seo
- Ofrat Beyar-Katz
- Kai Rejeski (ORCID: https://orcid.org/0000-0003-3905-0251)
- Mini Kamboj
- Michael Scordo
- Sham Mailankody
- Genovefa Papanicolaou
- Jaime Sanz
- Roni Shouval
- Silvia Escribano-Serrat
- Jae H Park
- Marina Gomez-Llobell
- Maria Isabel Sotelo-Alva
- Miguel-Angel Perales
- Judy Yan
Institutions
- Universitat Autònoma de Barcelona (ES)
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Rambam Health Care Campus (IL)
- LMU Klinikum (DE)
- Presbyterian Hospital (US)
- Duran i Reynals Hospital (ES)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1093/cid/ciag052
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00