Periodontitis promotes intestinal inflammation through gut microbiota–mediated suppression of GPR109A
Periodontitis promotes colonic inflammation by gut microbiota-induced suppression of GPR109A receptor, leading to the destruction of the epithelial barrier. Activation of GPR109A restores barrier function and attenuates inflammation.
Authors
- Mulong Du (ORCID: https://orcid.org/0000-0002-2733-6490)
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
- Hui Jia (ORCID: https://orcid.org/0000-0002-9706-227X)
- Yujie Yao
- Fuhua Yan
- Zhonghan Xu
- Xinyue Wang
- Shuangzheng Wang
Institutions
- Nankai University (CN)
- Stomatology Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fcimb.2026.1761932
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing University