Machine learning derived proliferating T cell-related signature: a novel biomarker for prognosis and treatment efficacy in clear cell renal cell carcinoma
The TRRS is a novel, validated biomarker that effectively predicts prognosis and therapeutic responses in advanced ccRCC. It reflects critical biological features of tumor aggressiveness and immune evasion, with CST3 emerging as a potential central mediator and therapeutic target.
Authors
- Xiuyi Pan
- Dingbang Liu
- Ling Wang
- Yanfeng Tang
- Hao Zeng
- Junjie Zhao
- Jiayu Liang
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.intimp.2026.116361
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00