Overdiagnosis of Papillary Thyroid Cancer
This study found that thyroid cancer overdiagnosis in the US remains substantial, even after accounting for possible increases in true incidence. This finding suggests an opportunity to reduce unnecessary thyroid ultrasonography referrals, particularly for nonpalpable nodules, and to reduce unnecessary diagnoses and treatment-related harms without increasing mortality.
Authors
- Y Zhang
- Rebecca A. Hubbard (ORCID: https://orcid.org/0000-0003-0879-0994)
- Peter Nordby (ORCID: https://orcid.org/0000-0002-1581-1530)
- Manasa Venkatesh (ORCID: https://orcid.org/0000-0002-6451-5252)
- David O. Francis (ORCID: https://orcid.org/0000-0003-1064-5892)
- Natalia Arroyo
- Louise Davies
- Sara Fernandes-Taylor
- Ben A. Y. Cher
- Oguzhan Alagoz
Institutions
- University of Wisconsin–Madison (US)
- Kaiser Permanente Washington Health Research Institute (US)
- Madison Area Technical College (US)
- University of Wisconsin Carbone Cancer Center (US)
- Wisconsin Division of Public Health (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.59852
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00