Erk3 deletion drives oxidative adaptations in skeletal muscle
Our study demonstrates that Erk3 is a key regulator of skeletal muscle oxidative remodeling and metabolic resilience. The deletion of Erk3 in muscles promotes energy expenditure in the myotubes by enhancing mitochondrial function and shifting fiber identity toward oxidative types. Thus, deletion of this kinase protects against high-fat diet-induced obesity, glucose intolerance, and insulin resistance.
Authors
- Grzegorz Sumara (ORCID: https://orcid.org/0000-0003-1502-6265)
- Katia El Ghoz
- Małgorzata Stelmach
- Filip Dziaczkowski (ORCID: https://orcid.org/0000-0003-4807-7456)
- Toufic Kassouf (ORCID: https://orcid.org/0000-0001-6011-880X)
- Andrei Belykh
- Angel Loza-Valdes
- Katarzyna Kolczyńska-Matysiak
- Dominika Malińska
- Rabih El-Merahbi
- Carlos Acosta-Gallo
Institutions
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- University of Würzburg (DE)
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.molmet.2026.102338
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung
- Max-Planck-Gesellschaft
- Narodowe Centrum Nauki
- Narodowym Centrum Nauki