Cross-species hepatic transcriptomics identify conserved immune-metabolic reprogramming in acute-on-chronic liver failure progression
This study defines a conserved immune-metabolic interplay during the progression of hepatitis B virus-related acute-on-chronic liver failure and validates the murine model's accuracy for studying the disease's terminal stage. The identified dysregulation of immune cells and metabolic pathways presents actionable targets for developing stage-specific therapies intended to disrupt the disease's vicious immune-metabolic cycle.
Authors
- Panyu Chen (ORCID: https://orcid.org/0000-0003-2174-954X)
- Zhaokai Zeng
- Min Shi (ORCID: https://orcid.org/0000-0002-2130-181X)
- Wenxi Su
- Yang Ren (ORCID: https://orcid.org/0009-0002-8431-6020)
- Yugang Wang
- Yun Song
- Chen Wang
- Kang He
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Renji Hospital (CN)
- XinHua Hospital (CN)
- Tongren Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fimmu.2026.1702689
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality