Case Report: Bevacizumab combined with chemotherapy followed by PARP inhibitor maintenance therapy in POLE-mutated primary fallopian tube carcinoma: a case of precision treatment in a rare gynecologic malignancy

This case demonstrates that Bev combined with chemotherapy may be an effective first-line regimen for this rare PTC variant. Maintenance therapy with a PARP inhibitor may prolong progression-free survival.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-02-24
DOI
https://doi.org/10.3389/fmed.2026.1696996
Primary Topic
Ovarian cancer diagnosis and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Case Report: Bevacizumab combined with chemotherapy followed by PARP inhibitor maintenance therapy in POLE-mutated primary fallopian tube carcinoma: a case of precision treatment in a rare gynecologic malignancy

Donghai Cheng, Xiujie Liu, Wenyuan He, Peng Liu et al.
Frontiers in Medicine
Ovarian cancer diagnosis and treatment
article

Case Report: Bevacizumab combined with chemotherapy followed by PARP inhibitor maintenance therapy in POLE-mutated primary fallopian tube carcinoma: a case of precision treatment in a rare gynecologic malignancy

Donghai Cheng, Xiujie Liu, Wenyuan He, Peng Liu, Xueqin Huang
article en

Abstract

This case demonstrates that Bev combined with chemotherapy may be an effective first-line regimen for this rare PTC variant. Maintenance therapy with a PARP inhibitor may prolong progression-free survival.

Frontiers in MedicineVol. 13
University of Nottingham Ningbo China (CN)
Good health and well-being
Openalex Percentile: Top 40%
Ovarian cancer diagnosis and treatment
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