Unraveling the anti-colorectal cancer mechanisms of Acanthopanax senticosus polysaccharide: a multi-omics investigation into gut microbiota-metabolism-immunity crosstalk
The results indicate that anti-CRC effect of ASP may be jointly regulated through multiple pathways: correcting abnormal glycerophospholipid and tryptophan metabolism in the host, restoring the homeostasis of the intestinal microbiota, increase the content of some SCFAs, and inhibiting the TLR4/NF-κB signaling pathway.
Authors
- Yu Guan (ORCID: https://orcid.org/0000-0001-7339-0087)
- Qichao Liang
- Jiaxin Jiang
- Xiwu Zhang
- Ling Kong
- Xijun Wang
- Chang Liu
- Le Yang
- Ye Sun
- Jie Zhang
- Di Han
- Hui Sun
- Ying Han
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Jiangsu Changjiang Electronics Technology (China) (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fphar.2026.1749532
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Heilongjiang Provincial Science and Technology Department