In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells
This is the first report demonstrating the differentiation of KNDy neurons from pluripotent stem cells, which can be applied to create cellular models for various diseases caused by KNDy peptide deficiency and may contribute to the development of novel therapeutic approaches and understanding cellular mechanisms regulating mammalian reproduction.
Authors
- Tsutomu Miwata
- Reina Sonehara (ORCID: https://orcid.org/0009-0004-2807-2177)
- Tomoko Nakamura (ORCID: https://orcid.org/0000-0001-5987-4384)
- Mika Soen
- Satoko Osuka (ORCID: https://orcid.org/0000-0002-4430-7982)
- Shiori Go
- Hidetaka Suga (ORCID: https://orcid.org/0000-0003-1924-7639)
- Ayako Muraoka (ORCID: https://orcid.org/0000-0003-2203-0844)
- Naoko Inoue (ORCID: https://orcid.org/0000-0002-4917-5261)
- Yoshihisa Uenoyama (ORCID: https://orcid.org/0000-0002-8272-2781)
- Mayu Sakakibara
- Saki Hasegawa
- Hiroshi Arima
- Bayasula
- Hiroko Tsukamura
- Tomomi Seki
- Hiroaki Kajiyama
Institutions
- Aichi Medical University (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1186/s12958-026-01536-x
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00