Safe dosage and potential risks of chlorogenic acid: insights from in vitro and in vivo studies
These findings suggest that the antioxidant and iron-chelating properties of CGA determine its role in either liver protection or toxicity at varying concentrations, providing valuable insight for its rational dietary and clinical use.
Authors
- Huaibin Zhou (ORCID: https://orcid.org/0000-0002-7897-1937)
- Liang Huang (ORCID: https://orcid.org/0000-0003-3233-4446)
- Binjie Ge (ORCID: https://orcid.org/0000-0003-3214-9566)
- Jianxin Lyu (ORCID: https://orcid.org/0000-0003-4505-4507)
- Mengyao Jiang
- Zheng Wang
- Guoqiang Tan
- Yilin Pang
- Xiaoyu Rao
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Wenzhou Medical University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Hangzhou Medical College (CN)
- Hunan Agricultural University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fphar.2026.1740609
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hunan Province
- Graduate Research and Innovation Projects of Jiangsu Province