PRMT1 regulates glioblastoma stemness and immunosuppression via nitric oxide metabolism: Multi-cohort analysis and experimental validation
PRMT1 links NO metabolism to glioma stemness and immunosuppression by regulating stemness factors (OCT4, SOX2) and immune checkpoints (PD-L1) through NO-dependent mechanisms. PRMT1 represents a therapeutic target that could disrupt stem cell populations and remodel the immunosuppressive microenvironment.
Authors
- Xinru Tian (ORCID: https://orcid.org/0000-0001-6570-6424)
- Haiying Wang
- Shuo Tang
- Yang Kong
- Ya Gao
- Kun Xue
- Caifeng Ma
Institutions
- Qingdao University (CN)
- Yuhuangding Hospital (CN)
- Yantaishan Hospital (CN)
Publication Details
- Journal
- Nitric Oxide
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.niox.2026.02.003
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00