The international, prospective COSMOS (CytOSorb® TreatMent Of Critically Ill PatientS) Registry: results from the first 300 patients
Real-world CytoSorb® use as part of standard care in critically ill patients was associated with improvements in several clinical and laboratory parameters; however, these findings should be interpreted cautiously given the observational design and absence of a control group. Observed mortality was lower than mortality estimates historically associated with established severity scores.
Authors
- Gabriella Bottari (ORCID: https://orcid.org/0000-0002-2723-9914)
- Bartosz Tyczynski
- Jorge Hidalgo (ORCID: https://orcid.org/0009-0005-2615-8150)
- Joerg Scheier (ORCID: https://orcid.org/0000-0003-0520-3133)
- Dana TOMESCU
- Matthias Thielmann (ORCID: https://orcid.org/0000-0002-1007-2871)
- Andreas Baumann (ORCID: https://orcid.org/0000-0001-5907-7895)
- Martin Bellgardt (ORCID: https://orcid.org/0000-0001-9447-0019)
- Efthymios Deliargyris (ORCID: https://orcid.org/0000-0002-1893-7024)
- Christina Scharf (ORCID: https://orcid.org/0000-0002-5310-4116)
- Philipp Hohlstein (ORCID: https://orcid.org/0000-0002-0796-8386)
- Teresa Klaus (ORCID: https://orcid.org/0009-0005-5236-0969)
- Thomas Kirschning
- Ricard Ferrer
- Markus Koestenberger
- Weihong Fan
- Nuno Germano
- Moritz Unglaube
- Thomas Guenther
- Andreas Kribben
- Filippo Aucella
- Mario Marquez Fernandez
- Julian Kreutz
- Jean-Louis Teboul
- P. Christian Schulze
- Aschraf El-Essawi
- Fabio Silvio Taccone
Institutions
- Université Libre de Bruxelles (BE)
- Philipps University of Marburg (DE)
- Carol Davila University of Medicine and Pharmacy (RO)
- Université Paris-Saclay (FR)
- Casa Sollievo della Sofferenza (IT)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- Helios Dr. Horst Schmidt Kliniken Wiesbaden (DE)
- LMU Klinikum (DE)
- Central America Health Sciences University (BZ)
- Klinikum Klagenfurt (AT)
- Vall d'Hebron Institut de Recerca (ES)
- Klinikum Oldenburg (DE)
- CytoSorbents (Germany) (DE)
- Essen University Hospital (DE)
- Bambino Gesù Children's Hospital (IT)
- Hospital Juan Ramón Jiménez (ES)
- Herford Hospital (DE)
- Hospital Curry Cabral (PT)
- Jena University Hospital (DE)
- St. Josef-Hospital (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- CytoSorbents (United States) (US)
- Deutsches Herzzentrum München (DE)
- Institutul Clinic Fundeni (RO)
- West German Heart and Vascular Center Essen (DE)
- University of Duisburg-Essen (DE)
- Ludwig-Maximilians-Universität München (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Journal of Anesthesia Analgesia and Critical Care
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1186/s44158-026-00362-2
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00