Hutchinson-Gilford progeria syndrome alters the endothelial genetic response to laminar shear stress
These observations indicate that HGPS ECs have an aberrant molecular response to atheroprotective shear stress, including impaired elongation and upregulation of the pro-inflammatory gene LGALS3, which contributes to atherogenesis in HGPS patients.
Authors
- Jonathan Ambrose Carr (ORCID: https://orcid.org/0000-0002-7677-426X)
- Crystal C. Kennedy (ORCID: https://orcid.org/0000-0003-3405-3381)
- George A. Truskey
Institutions
- Duke University (US)
- Institut thématique Génétique, génomique et bioinformatique (FR)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fphys.2025.1599339
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harvard University
- Broad Institute
- National Institutes of Health