Methyl-4-hydroxybenzoate induces osteoporosis via the AKT1/LC3B/Beclin1 autophagy signaling pathway: Integrating network toxicology and experimental validation
Collectively, this study demonstrates that the environmental pollutant methylparaben (MEP) induces OP by suppressing AKT1-mediated autophagy signaling. Our findings provide novel mechanistic insights into how ecological contaminants may trigger OP pathogenesis, thereby establishing a theoretical foundation for the development of preventive and therapeutic strategies against pollutant-associated bone disorders.
Authors
- Jingyi Huang (ORCID: https://orcid.org/0000-0002-1209-9699)
- Yi Shen (ORCID: https://orcid.org/0000-0001-8403-9882)
- Wenhao Wang (ORCID: https://orcid.org/0000-0002-0971-4232)
- Xiang Gao (ORCID: https://orcid.org/0000-0001-5507-4232)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- D. B. Tang
- Senjie Shi
- Chuanglong Xu
- Furui Fu
- Mengting Yuan
- Yunqi Li
- Haitao Zhang
- Tianpeng Liu
Institutions
- Shenzhen University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Huadong Hospital (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Ningxia Hui Autonomous Region Peoples Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.ecoenv.2026.119913
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00