Cross-tissue integrative transcriptomic and multimodal analyses suggest shared immune signatures linking lupus nephritis and cutaneous lupus erythematosus
This integrative analysis establishes a shared molecular signature between LN and CLE. The identified hub genes represent promising hypothesis-generating molecular signatures and hypothesis-generating therapeutic targets, with potential to improve risk stratification, guide early intervention, and support precision medicine approaches for lupus comorbidities.
Authors
- Hongyun Zhao (ORCID: https://orcid.org/0000-0002-1251-3888)
- Linyu Zhu (ORCID: https://orcid.org/0000-0003-1822-3221)
- Songjuan Wang
- Yong Li (ORCID: https://orcid.org/0000-0003-4038-0493)
- Changze Song
- Huisheng Yuan
- Hongcheng Sun
- Z. Zhang
- Zilong Wang
- Meilu Li
- Di Wang
- Yu Sun
Institutions
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fimmu.2026.1716516
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00