Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression
The H3.3<sup>low</sup>/ERE<sup>high</sup> signature may not only explain the common skewed myelopoiesis in MS and post-COVID-19 conditions, but also provide a mechanistic link between infection and the innate immune reprogramming that drives MS progression. This offers a novel therapeutic insight for MS.
Authors
- Runhua Li (ORCID: https://orcid.org/0000-0002-2173-1430)
- Wan-jin CHEN
- H. Song
- Wei Chen (ORCID: https://orcid.org/0009-0000-0883-2547)
- Q. Zhao
- Li-Mei Xiao
- Wei Chen
- Ying Fu
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1002/acn3.70350
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00