Synergistic effects of ceftriaxone combined with BLI-489 against NDM-producing <i>Klebsiella pneumoniae</i>

The global spread of NDM-Kp poses a major challenge to healthcare systems because of the scarcity of effective treatment options. In response to the urgent need for new therapeutic strategies, this study explores the CRO/BLI-489 as a promising alternative for overcoming MBL-mediated resistance. Although not yet an established therapy, this approach demonstrates the potential to restore cephalosporin efficacy, inhibit biofilm formation, and reduce cytotoxicity. These results offer valuable insights that may guide the development of future treatments for infections caused by multidrug-resistant pathogens. Our findings underscore the importance of further preclinical and clinical studies to validate this strategy and contribute to the global effort against antibiotic resistance.