Comparative efficacy of intravenous, topical, and combined tranexamic acid in elderly patients with intertrochanteric fractures undergoing intramedullary nail fixation: a multicenter cohort study
In older adults undergoing intramedullary fixation for intertrochanteric fractures, TXA reduces blood loss without increasing complications, with greatest benefit from combined intravenous plus topical use. These findings support TXA as a key component of perioperative blood management in this population.
Authors
- Xiongfei Zou
- Y.-J. Li (ORCID: https://orcid.org/0009-0009-2742-0826)
- Qiushi Bai (ORCID: https://orcid.org/0000-0001-5022-4115)
- Hongbo Zhang
- YongMing Yang
- Baozhong Zhang
- Kunyu Ji
- Xiao Chang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Longmont United Hospital (US)
- Peking Union Medical College Hospital (CN)
- County Hospital (GB)
- Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fphar.2026.1775124
- Primary Topic
- Hip and Femur Fractures
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital
- Peking Union Medical College