LSD1 Performs Demethylase-Independent and Context-Specific Roles in Ewing Sarcoma
In this study, we address a long-standing question in the field surrounding LSD1 and define the distinct enzymatic and nonenzymatic functions of LSD1 in Ewing sarcoma. In doing so, we have created a robust data set using genetic and pharmacologic techniques in multiple models to thoroughly characterize LSD1 function in Ewing sarcoma cell lines.
Authors
- John Sherman (ORCID: https://orcid.org/0000-0002-7998-9979)
- Ariunaa Bayanjargal (ORCID: https://orcid.org/0000-0003-3841-3241)
- Rachel D. Dreher (ORCID: https://orcid.org/0000-0002-9041-624X)
- Emily Theisen
- Ira Miller
- Cenny Taslim
Institutions
- Nationwide Children's Hospital (US)
- The Ohio State University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0765
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 22.24
Funders
- Ohio State University
- Nationwide Children's Hospital
- CancerFree KIDS
- National Institutes of Health