SIRT1 regulates dermal fibroblast senescence via impaired deacetylase function and mitochondrial dysfunction during skin aging induced by chronic oral cadmium exposure
Our findings position SIRT1 as a crucial regulator of Cd-induced skin aging and suggest that targeting this deacetylase may provide a viable strategy to counteract skin degeneration caused by environmental insults.
Authors
- Qunchao Su
- Yonggang Ma (ORCID: https://orcid.org/0009-0004-8108-0723)
- Xiaohui Fu
- Gengsheng Yu
- Zongping Liu
- Dehui Zhou
- Di Ran (ORCID: https://orcid.org/0009-0003-3433-3495)
- Hui Zou
- Chu Wang
Institutions
- Southwest University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3389/fpubh.2026.1779372
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00