AMPK Deficiency Induces Corneal Epithelial Barrier Dysfunction by Modulating Energy Homeostasis
This study suggests that energy metabolism disruption plays a pivotal role in corneal barrier dysfunction, and elucidates the metabolic and biological functions of AMPKα in the corneal epithelium, which may serve as a potential therapeutic target for ocular surface diseases associated with compromised barrier function.
Authors
- Mingyan Wei
- Yiran Yang (ORCID: https://orcid.org/0000-0003-2688-6340)
- Linfangzi Zhu
- Shengwei Ren (ORCID: https://orcid.org/0000-0002-9434-8598)
- Yunlan Tang (ORCID: https://orcid.org/0009-0008-6287-8843)
- Zheng Liu (ORCID: https://orcid.org/0000-0002-4252-4617)
- Ke Yan
- Dongqing Zhao
- Caihong Huang
Institutions
- Henan University (CN)
- Xiamen University (CN)
- Henan Provincial People's Hospital (CN)
- First Affiliated Hospital of University of South China (CN)
- Henan Provincial Eye Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1167/iovs.67.2.47
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00