Associations among Symptoms, Gastroscopic Findings, and Electrogastrography Parameters in Patients with Functional Dyspepsia: A Retrospective Cross-sectional Study

Functional dyspepsia (FD) is a common condition diagnosed by chronic symptoms like postprandial fullness or epigastric pain, complicated by diverse pathophysiological mechanisms. This retrospective study analyzed 247 FD patients (Mar 2010–May 2025) who had chronic dyspepsia (≥3 months) and prior esophagogastroendoscopy(EGD), along with electrogastrography (EGG) results, to inform diagnostic and therapeutic approaches. Of the patients (mean age 49.98±14.84 years), 79.8% reported bloating, and 69.9% reported two or more symptoms. Data collected included EGD results (gastritis, esophagitis, or normal), 36.4% had normal EGD findings. Multivariable logistic regression showed that esophagitis was significantly associated with heartburn (OR=2.62) and regurgitation (OR=2.47). Furthermore, multivariable linear regression analysis of EGG indices revealed that symptoms such as vomiting (postprandial ch1) and regurgitation (postprandial ch2) were associated with increased bradygastria ratios. Heartburn was associated with an increased postprandial ch4 arrhythmia ratio (B=5.073). FD patients frequently exhibit overlapping symptoms and coexisting conditions like esophagitis and gastric motility issues. Clinicians should consider these overlapping diagnoses and gastric motility problems when patients report symptoms like heartburn and regurgitation with chronic dyspepsia.