A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients
In hospitalized patients with chronic hyponatremia, a targeted correction intervention resulted in higher normonatremia rates but did not reduce a composite outcome of 30-day mortality and rehospitalization. (Funded by the Swiss National Science Foundation [grant number, 33 IC30_192979]; ClinicalTrials.gov number, NCT03557957.).
Authors
- Svenja Ravioli (ORCID: https://orcid.org/0000-0003-1375-8112)
- Markus Köster (ORCID: https://orcid.org/0000-0001-9883-0608)
- Sadrija Cukoski (ORCID: https://orcid.org/0000-0002-6427-177X)
- Ivana Dora Vodanović (ORCID: https://orcid.org/0000-0002-5380-4411)
- Volker Burst (ORCID: https://orcid.org/0000-0002-0256-6628)
- Basil Ryser (ORCID: https://orcid.org/0000-0002-8870-0591)
- Dario Norello (ORCID: https://orcid.org/0000-0001-9784-2287)
- Claudia Gregoriano (ORCID: https://orcid.org/0000-0002-3621-441X)
- D. Vogt (ORCID: https://orcid.org/0000-0002-0668-5675)
- Jörg D. Leuppi (ORCID: https://orcid.org/0000-0002-5554-0675)
- Laura Werlen (ORCID: https://orcid.org/0000-0001-5042-8353)
- Gregor Lindner (ORCID: https://orcid.org/0000-0001-5551-8227)
- Maria Boesing (ORCID: https://orcid.org/0000-0001-8605-1893)
- Sven Lustenberger (ORCID: https://orcid.org/0009-0002-2091-8460)
- Anissa Pelouto (ORCID: https://orcid.org/0000-0002-0143-4121)
- Lana Šambula
- Sophie Monnerat (ORCID: https://orcid.org/0000-0002-0179-7889)
- Adrienne A.M. Zandbergen (ORCID: https://orcid.org/0000-0001-5056-5921)
- Joyce Santos de Jesus (ORCID: https://orcid.org/0009-0000-9587-5421)
- Julia Beck (ORCID: https://orcid.org/0009-0007-8556-1075)
- Beat Mueller
- Bilz Stefan
- Nikola Rapsch
- Martina Luisa Bontognali
- Ewout Hoorn
- Alessandro Peri
- Moritz Trappe
- Philipp Schuetz
- Julie Refardt
- Laura Potasso
- Mirjam Christ-Crain
- Darko Kastelan
Institutions
- Johannes Kepler University of Linz (AT)
- University Hospital Centre Zagreb (HR)
- University of Cologne (DE)
- University of Basel (CH)
- University of St.Gallen (CH)
- Erasmus MC (NL)
- University Hospital of Basel (CH)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Kepler Universitätsklinikum (AT)
- Schweizerische Ärztegesellschaft für Psycholytische Therapie (CH)
- Solothurner Spitäler (CH)
- University Hospital Cologne (DE)
- Kantonsspital Aarau (CH)
- University of Florence (IT)
Publication Details
- Journal
- NEJM Evidence
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1056/evidoa2500086
- Citations
- 1
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 36.44