The Association Between Leptin and Asprosin Levels in Men Patients with Type II Diabetes Mellitus

Leptin and Asprosin are adipokines secreted by Adipose tissue. The leptin and asprosin molecules have a number of functions in the central nervous system and other body systems: appetite, glucose metabolism, insulin resistance, and cellular death. The point of this study is to know the potential relationship between leptin and asprosin hormone in men patients with type II diabetes mellitus. The present study was designed to conduct a comparative analysis of several essential biomarkers found in the sera of individuals with diabetes via estimating Leptin, Asprosin, Fasting blood Glucose, HbA1c, Body Mass Index, lipid profile as well as liver function testes with type II diabetes mellitus. The study groups consist of 60 sample that were separated into two groups: group I consisted of 30 diabetic men, and group II included 30 healthy men. Biochemical parameters of every participant were ascertained. The quantification of leptin and asprosin in serum was conducted using an enzyme-linked immunosorbent assay. According to the results of this investigation, levels of leptin, asprosin, Fasting blood Glucose and HbA1c were markedly high for type II diabetes mellitus group compared with control group [(5.72 ± 1.05), (10.47 ± 2.14), ( 209.97 ± 49.71 ), and ( 9.40 ± 1.31 )] respectively, with a significant difference (P = 0.001). Elevated concentrations of leptin and asprosin in the serum of patients were associated with inadequate glycemic control. A positive association appears to exist between leptin and asprosin in patients. The study concluded that leptin and asprosin are diagnostic factor for type II diabetes mellitus.