Dual calcium-ACE inhibition reverses non alcoholic fatty pancreas progression: Mechanistic convergence on miR-762/GPX4 driven NLRP3 inflammasome activation
These findings position miR-762 as a linchpin biomarker connecting metabolic stress to ferroptotic pancreatitis, with clinical translation challenges. This work provides the first evidence that sub-therapeutic calcium-RAS crosstalk modulation can reverse established pancreatic steatosis while outlining a precision medicine framework for NAFP prevention.
Authors
- Marian Maher Salib Roushdy
- Nevien Hendawy (ORCID: https://orcid.org/0000-0003-0200-1034)
- Radwa Khaled (ORCID: https://orcid.org/0000-0002-4566-9803)
- Ghada Galal Hamam (ORCID: https://orcid.org/0000-0001-6562-2132)
- Nesma Mohamed
- Tarek Mohamed Yousef
- Aly ELanwar
- Marwa Matboli
- Marwa Shafei
- Shimaa S. Attia
- Maha Saad
- Mohamed Ahmed Mohamed Tolba
Institutions
- Ain Shams University (EG)
- Gulf Medical University (AE)
- Modern University for Information and Technology (EG)
- Dubai Medical College (AE)
- Misr International University (EG)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.biopha.2026.119137
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00