Discoidin Domain Receptor 1 Translocation to the Mitochondria Promotes Oxidative Stress and Apoptosis in Acute Kidney Injury
We describe a novel non-canonical pathway whereby activated DDR1 translocates to the mitochondria to promote oxidative stress and cell apoptosis.
Authors
- Shirong Cao (ORCID: https://orcid.org/0000-0002-6593-4600)
- Oscar Hanson
- Roy Zent (ORCID: https://orcid.org/0000-0003-2983-8133)
- Craig R. Brooks (ORCID: https://orcid.org/0000-0001-8113-2993)
- Fabian Bock
- Xinyu Dong (ORCID: https://orcid.org/0000-0002-3017-2634)
- Ambra Pozzi (ORCID: https://orcid.org/0000-0001-8502-1481)
- Manuel Chiusa (ORCID: https://orcid.org/0000-0002-5017-1153)
- Corina M. Borza (ORCID: https://orcid.org/0000-0001-9113-110X)
- Gema Bolás (ORCID: https://orcid.org/0000-0001-7809-1959)
- Ming-Tsun Tsai
- Agnes B. Fogo
- Ming-Zhi Zhang
Institutions
- Vanderbilt University Medical Center (US)
- Berea College (US)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1681/asn.0000001045
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00