Age-dependent changes in the transverse carpal ligament and median nerve: a cadaveric histological and biomechanical study
This cadaveric study reveals that the TCL stiffens and becomes structurally disorganized with advancing age, paralleled by degenerative changes in the median nerve. Such age-related alterations may predispose elderly individuals to a higher risk of carpal tunnel syndrome, underscoring the need for targeted preventive and therapeutic strategies.
Authors
- Benjaporn Pamornpol
- Akkradate Siriphorn (ORCID: https://orcid.org/0000-0002-0652-9146)
- Apichaya Niyomchan
- Kanet Kathinted
Institutions
- Siriraj Hospital (TH)
- Chulalongkorn University (TH)
- Mahidol University (TH)
Publication Details
- Journal
- PeerJ
- Published
- 2026-02-24
- DOI
- https://doi.org/10.7717/peerj.20878
- Primary Topic
- Peripheral Nerve Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00