Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients
The TCA index serves as a novel indicator of ischemic mitochondrial stress and a robust independent predictor of adverse outcomes in AMI. This metabolic algorithm offers complementary prognostic value to existing clinical models, aiding risk stratification for post-infarction care.
Authors
- Zhanchao Chen
- Miao Yan
- S Y Wang
- Ye Wang
- Bo Yu
- Yiying Zhang
- Shaohong Fang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Jiamusi University (CN)
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Ministry of Education (BN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Institute of Zoology (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1186/s12916-026-04717-y
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00