Early response of total neoadjuvant therapy with regional deep hyperthermia for low-lying locally advanced rectal cancer: a single-center retrospective study
Combining TNT with regional deep HT for low-lying LARC is a promising treatment strategy that improves tumor response rates, complete remission rates, and tumor downstaging while maintaining acceptable toxicity profiles. Further prospective randomized studies are warranted to confirm these findings and establish the role of HT in neoadjuvant protocols.
Authors
- Zohier Srour
- Günther Klautke
- Lutz Mirow (ORCID: https://orcid.org/0000-0002-4697-6223)
- Griseldis Petzold
- Kristin Tischendorf
- Jöhrens Korinna
- Hagen Rudolph
- Julia Klaus
- Paul Warncke
- Nicole Klinge
- Matthias Berger
- Michael Schöpe
- Marc Golombeck
- Mathias Hänel
Institutions
- Diakonissenkrankenhaus (DE)
- Krankenhaus Bethanien (DE)
- Evangelisches Diakoniekrankenhaus (DE)
- Gemeinschaftsklinikum Mittelrhein (DE)
- University Hospital Carl Gustav Carus (DE)
- Klinikum Chemnitz (DE)
Publication Details
- Journal
- Strahlentherapie und Onkologie
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1007/s00066-026-02512-5
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 0.00