Management of Liver Cirrhosis in Percutaneous and Surgical Cardiac Interventions

The systemic impairment that accompanies liver cirrhosis is known to carry a significant burden on death and postoperative complications in cardiovascular interventions. This review analyzes the impact of liver cirrhosis on short- and long-term outcomes after cardiac surgery and percutaneous procedures, providing an evidence-based guidance in the decision-making process and perioperative management of these patients. Several parameters should be considered by the heart teams when assessing eligibility, indications for intervention, and perioperative management of these patients. Life expectancy, long-term procedural outcomes, Child-Pugh or the Model for End-Stage Liver Disease score, presence of gastroesophageal varices and hepatic venous pressure gradient were extrapolated as the main determinants in decision making in patients with cirrhosis. Assessment and treatment of gastroesophageal varices is mandatory. Hepatic venous pressure gradient values >20 mm Hg preclude patients from a surgical approach. Considering the poor prognosis of advanced liver cirrhosis, futile treatments should be avoided. A multidimensional heart team approach involving surgical, cardiologic, anesthesiologic, hepatological, and medical considerations is recommended.

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Publication Details

Journal
Journal of the American Heart Association
Published
2026-02-24
DOI
https://doi.org/10.1161/jaha.125.045147
Primary Topic
Liver Disease and Transplantation
Type
article
Field-Weighted Citation Impact
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article

Management of Liver Cirrhosis in Percutaneous and Surgical Cardiac Interventions

C. Spadaccio, Louis B. Louis, D. L. ROSE, Krishna Mehta et al.
Journal of the American Heart Association
Liver Disease and Transplantation
article

Management of Liver Cirrhosis in Percutaneous and Surgical Cardiac Interventions

C. Spadaccio, Louis B. Louis, D. L. ROSE, Krishna Mehta, Angelo Pisani, Antonio Panza, Antonio Nenna, Domenico Alvaro, Juan Crestanello, Asishana Osho, Thoralf M. Sundt, Fernando Juarez‐Casso, Russell S. Vester, Imran Arif
article en

Abstract

The systemic impairment that accompanies liver cirrhosis is known to carry a significant burden on death and postoperative complications in cardiovascular interventions. This review analyzes the impact of liver cirrhosis on short- and long-term outcomes after cardiac surgery and percutaneous procedures, providing an evidence-based guidance in the decision-making process and perioperative management of these patients. Several parameters should be considered by the heart teams when assessing eligibility, indications for intervention, and perioperative management of these patients. Life expectancy, long-term procedural outcomes, Child-Pugh or the Model for End-Stage Liver Disease score, presence of gastroesophageal varices and hepatic venous pressure gradient were extrapolated as the main determinants in decision making in patients with cirrhosis. Assessment and treatment of gastroesophageal varices is mandatory. Hepatic venous pressure gradient values >20 mm Hg preclude patients from a surgical approach. Considering the poor prognosis of advanced liver cirrhosis, futile treatments should be avoided. A multidimensional heart team approach involving surgical, cardiologic, anesthesiologic, hepatological, and medical considerations is recommended.

Journal of the American Heart AssociationVol. 15(5)
University of Liverpool (GB), Blackpool Victoria Hospital (GB), WinnMed (US), Massachusetts General Hospital (US), Campus Bio Medico University Hospital (IT), Hôpital Bichat-Claude-Bernard (FR), Lancaster University (GB), Sapienza University of Rome (IT), University of Cincinnati Medical Center (US)
Openalex Percentile: Top 47%
Liver Disease and Transplantation
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