METTL3 Potentiates Corneal Allograft Rejection via Increased Pro-Inflammatory Cytokine Production and Aerobic Glycolysis
Our findings highlight a critical role for METTL3 in promoting corneal transplant rejection. Targeting METTL3 may represent a potential therapeutic strategy to improve corneal allograft survival, providing valuable insights for future clinical translation.
Authors
- Haining Yu (ORCID: https://orcid.org/0000-0002-4996-3233)
- Junpeng Qu
- Fanxing Zeng (ORCID: https://orcid.org/0000-0003-1306-5578)
- Chao Wei
- C. Wei
- H Gao
- Xiaoxue Liu
Institutions
- Qingdao University (CN)
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1167/iovs.67.2.48
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province