Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids
Ascites-derived OC PDOs represent a robust platform for individualized drug testing. The combination of OH2 and cisplatin offers a novel and effective strategy for circumventing chemoresistance in OC.
Authors
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Huiqin Guo
- Duo Wan
- Kaitai Zhang
- Qi Zhang
- Ning Li
- Ying Cui
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1186/s12916-026-04730-1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00