Absolute Quantification of Brain Deuterium Metabolic Imaging in Healthy Volunteers and Glioblastoma Patients at <scp>7T</scp>
We demonstrate robust absolute quantification for human 7T DMI. Glioblastoma tumors showed elevated Lac and reduced Glx labeling relative to normal brain, with inter-patient heterogeneity consistent with an existence of different metabolic subtypes.
Authors
- Christopher T. Rodgers (ORCID: https://orcid.org/0000-0003-1275-1197)
- Carina Graf (ORCID: https://orcid.org/0000-0003-4281-3432)
- Brandon Tramm
- M. Zhang
- Sarah E. Miller (ORCID: https://orcid.org/0000-0002-5558-1813)
- Özlem İpek (ORCID: https://orcid.org/0000-0001-5233-1600)
- K. Brindle
- Scott Schillak
- Daniel Atkinson
- Masha Novoselova (ORCID: https://orcid.org/0009-0005-5043-6261)
- R. Mair
- Jabrane Karkouri
- Alexandra Constantinou
Institutions
- King's College London (GB)
- University of Cambridge (GB)
- Cancer Research UK Cambridge Center (GB)
- King's College School (GB)
- VIR Biotechnology (United States) (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1002/mrm.70308
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00