A Correlation between Leptin Hormone and Other Biochemical Parameters in Iraqi Women with Hepatitis C Virus (HCV) in Thi-Qar Governorate in Iraq

Background: chronic hepatitis C virus (HCV) infection is a major health problem. Females of childbearing age who are infected with hepatitis C are exposed to premature aging of the ovaries, which leads to an imbalance in the levels of sex hormones leptin hormone is associated with all stages of reproductive age. The aim of the present study is to observe levels the liver enzyme, Albumin, total bilirubin, estrogen, progesterone and leptin hormone. Also to evaluate the correlation between ( leptin hormone liver enzyme, Albumin, total bilirubin, estrogen and progesterone ).Methods: Serum liver enzyme, Albumin, total bilirubin, estrogen, progesterone and leptin hormone levels were determined in 33 patients with HCV and 32 healthy subjects. Results: When compared to the control group, the levels of liver enzyme, total bilirubin, estrogen, progesterone and leptin hormone were significantly higher in patients with hepatitis C virus (P ≤ 0.05). On in contrary, levels of Albumin indicated a considerable decrease in patients having hepatitis C virus compared with control subjects (P ≤ 0.05). The present study has reported a positive correlation between leptin hormone and (liver enzyme, total bilirubin, estrogen and progesterone ). Also it has revealed negative correlation between leptin hormone and Albumin.