Comparative proteomic analysis of gingival crevicular fluid and periodontal tissue: revealing clinical potential

This comparative proteomic analysis demonstrates that periodontal tissue and GCF represent functionally distinct but complementary biological environments in periodontitis. Periodontal tissue exhibits enhanced structural and metabolic processes, whereas GCF predominantly reflects neutrophil-mediated immune responses. These molecular distinctions provide a basis for developing clinical, compartment-specific biomarker candidates that warrant analytical validation, thereby supporting precision-medicine-relevant diagnostic strategies in periodontal research.