Long-term cervical cancer risk following negative hrHPV-based versus negative cytology-based screening: A population-based study
A negative hrHPV test was linked to lower long-term risk of cervical cancer than normal cytology, supporting longer screening intervals for hrHPV-negative women. However, hrHPV-positivity with negative cytology was associated with increased risk, suggesting the possible need for alternative triage guidelines.
Authors
- de Kok Im
- Erik E. L. Jansen (ORCID: https://orcid.org/0000-0003-0436-6918)
- Albert G. Siebers (ORCID: https://orcid.org/0000-0002-6085-0678)
- Veerle J. C. Schevenhoven (ORCID: https://orcid.org/0009-0001-2812-6647)
Institutions
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.ejca.2026.116601
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Rijksinstituut voor Volksgezondheid en Milieu