Handheld Embedded Laser‐Diode Illumination Optoacoustic System for Real‐Time 3D Angiography of Deep Tissues

The clinical adoption of optoacoustic imaging is currently being impeded by the bulky design and high cost of traditional systems based on solid‐state lasers. We introduce a cost‐effective, high‐performance Handheld Embedded Laser‐diode Illumination Optoacoustic System (HELIOS) based on a spherical array probe incorporating a compact illumination source located in close proximity to the imaged object. High performance drivers have been designed to produce 1.8 mJ energy pulses at 915 nm wavelength, sufficient for rendering entire ≈1 cm $^{3}$ image volumes with high spatial and temporal resolution. The fast imaging performance is further facilitated by high‐speed acquisition electronics capable of simultaneous sampling of all 256 transducer channels, thus enabling volumetric imaging at up to 400 Hz frame rate corresponding to pulse repetition frequency of the laser diodes. HELIOS attains image quality and performance metrics on par with those achieved with solid state laser sources. We then demonstrate real‐time volumetric angiography of human fingers and palm in a freehand mode, perform large‐scale volumetric compounding of vascular structures from the time‐lapse 3D data, and visualize vessel perfusion and pulsation with the system. The work represents a major leap toward the translation of optoacoustics into point‐of‐care diagnostics and enabling its dissemination in resource‐limited settings.