Lactate-Driven IL8+ Tumor-Associated Macrophages Mediate Immunosuppression and Resistance to Immunotherapy in Clear-Cell Renal Cell Carcinoma
IL8+ TAMs represent a metabolically reprogrammed and immunosuppressive subset driving ICB resistance in ccRCC. Targeting IL8 may overcome resistance and enhance immunotherapy efficacy.
Authors
- Yi Qu (ORCID: https://orcid.org/0000-0002-9993-8810)
- Jiangting Cheng (ORCID: https://orcid.org/0009-0005-8906-3773)
- Jiejie Xu (ORCID: https://orcid.org/0000-0001-7431-9063)
- Youqi Qiu
- Ziyang Xu (ORCID: https://orcid.org/0009-0003-5711-5159)
- Wenbin Jiang (ORCID: https://orcid.org/0000-0001-6434-533X)
- Jianming Guo (ORCID: https://orcid.org/0009-0009-6535-9317)
- Yu Xia
- Li Liu
- Yu Dong
- Siyuan Dai
- Peiqing Ke
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-4384
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- Shanghai Municipal Health Bureau