Patient-Derived Immortalized Limbal Epithelial Cells as In Vitro Models of Congenital Aniridia
Immortalized aniridia limbal epithelial cell lines preserve key epithelial characteristics and overall transcriptomic similarity to controls while exhibiting disease-relevant molecular alterations. These cell lines represent models of PAX6-associated ocular surface disease.
Authors
- Frank Schmitz (ORCID: https://orcid.org/0000-0002-9090-0277)
- Tobias May (ORCID: https://orcid.org/0000-0002-4042-4815)
- Shweta Suiwal (ORCID: https://orcid.org/0000-0002-1230-1279)
- Nóra Szentmáry (ORCID: https://orcid.org/0000-0001-8019-1481)
- Virendra Kumar (ORCID: https://orcid.org/0000-0003-4536-9496)
- Shao-Lun Hsu
- Shanhe Liu
- S. Li
- S. Kundu
- Nicole Ludwig
- Maryam Amini
- Fabian N. Fries
- Tanja Stachon
- Berthold Seitz
Institutions
- Institute of Human Genetics (PL)
- Saarland University (DE)
- Technische Universität Braunschweig (DE)
Publication Details
- Journal
- Cells
- Published
- 2026-02-24
- DOI
- https://doi.org/10.3390/cells15050394
- Primary Topic
- Developmental Biology and Gene Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00