Triglyceride-rich lipoproteins, low-density lipoproteins, and risk of abdominal aortic aneurysm
TRLs are at least threefold more aneurysmogenic than LDLs on a per-particle basis. Therapeutic strategies targeting TRL-C -especially via <i>APOC3</i> and <i>LPL</i>-should be prioritized for AAA prevention and treatment.
Authors
- Shaunak Adkar (ORCID: https://orcid.org/0000-0002-8893-2413)
- Ryan E Temel
- Gabrielle E. Shakt (ORCID: https://orcid.org/0009-0001-9599-6351)
- Hong Lu (ORCID: https://orcid.org/0000-0002-8529-441X)
- Alan Daugherty
- Phil Tsao
- Nicholas Leeper
- Kyong-Mi Chang
- Shuai Yuan
- Tia Dinatale
- Julie Lynch
- Scott M. Damrauer
- Michael Levin
- Elias Bjornson
Institutions
- University of Kentucky (US)
- California University of Pennsylvania (US)
- VA Salt Lake City Healthcare System (US)
- Philadelphia VA Medical Center (US)
- University of Pennsylvania (US)
- University of Gothenburg (SE)
- Stanford University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-24
- DOI
- https://doi.org/10.64898/2026.02.22.26346555
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- U.S. Department of Veterans Affairs
- American Heart Association
- Amgen
- AstraZeneca
- Office of Research and Development
- Alnylam Pharmaceuticals
- Arrowhead Pharmaceuticals
- VIVA Foundation for Children with Cancer
- Hjärt-Lungfonden
- Novo Nordisk
- National Institutes of Health
- Office of Science
- National Heart, Lung, and Blood Institute
- Janssen Pharmaceuticals
- Oak Ridge National Laboratory