Triple Therapy: A Safe, Cost-Effective Regimen of Heparin, Aspirin and Clopidogrel for Managing Intracranial Vessel Occlusions in Patients With Acute Ischemic Stroke Who Are Ineligible for Intravenous Thrombolytics and Endovascular Thrombectomy
Short-term TT demonstrated low rates of hemorrhage, with zero symptomatic intracranial hemorrhages, and may represent a safe, cost-effective option for managing select patients with ischemic stroke with intracranial occlusions who are ineligible for intravenous thrombolysis or EVT. However, the observed clinical outcomes may be confounded by the discrepancy between the 2 populations' baseline stroke severity. Further prospective studies are necessary to validate the role of TT and optimize its integration into clinical practice.
Authors
- Anjan Bhattarai (ORCID: https://orcid.org/0000-0003-3508-9642)
- Amit Chaudhari (ORCID: https://orcid.org/0009-0004-6393-5169)
- Fawwaz Almajali (ORCID: https://orcid.org/0000-0002-3777-2448)
- Eugene C. Lin (ORCID: https://orcid.org/0000-0002-9780-4982)
- Kaustubh Limaye (ORCID: https://orcid.org/0000-0002-7280-7407)
- Mohammad AlMajali
- Jaafar Kashef Al-Gheeta
- Niha Khan
- Ann Jones
- Thanh Nguyen
- Shadi Yaghi
- Yazan Ashouri
- Osama O. Zaidat
Institutions
- Indiana University Health (US)
- Boston Medical Center (US)
- Tufts Medical Center (US)
- Mercy St. Vincent Medical Center (US)
- Saint Louis University (ES)
- Brown University (US)
- Saint Louis University Hospital (US)
- Saint Louis University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Stroke Vascular and Interventional Neurology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1161/svin.125.002175
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00