Biomechanical Modification of the Sclera: An Ex Vivo Study on Porcine Eyes
COL, GAD, and mTG induced dose-responsive biomechanical changes in ex vivo scleral biomechanics with acceptable safety. Locally applied treatments showed reduced biomechanical impact compared with strip incubation. Further experiments need to confirm these findings in vivo and determine its role in diseased eyes.
Authors
- Michael Nahmou (ORCID: https://orcid.org/0000-0002-6471-8156)
- David Myung (ORCID: https://orcid.org/0000-0002-7980-3070)
- Kyeongwoo Jang (ORCID: https://orcid.org/0000-0002-3665-2698)
- Anthony B. Ross
- Jeffrey L. Goldberg (ORCID: https://orcid.org/0000-0002-1390-7360)
- Charles DeBoer (ORCID: https://orcid.org/0000-0003-1308-0583)
- Bryce Chiang
- Hyeonji Kim
Institutions
- Johns Hopkins University (US)
- Smith-Kettlewell Eye Research Institute (US)
- Technical University of Munich (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1167/iovs.67.2.51
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00