Body Composition Changes in Children Living With HIV Initiated on Dolutegravir or Protease Inhibitors in the CHAPAS-4 Trial

DTG and ATV/r were associated with greater gains in fat-free mass and muscle mass than LPV/r, while DRV/r, TAF and prior nevirapine exposure were associated with fat mass accrual. Fat gain may initially reflect return to health but sustained increases may have metabolic implications. These findings suggest the need to monitor fat compartments with long-term exposure.

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Publication Details

Journal
The Pediatric Infectious Disease Journal
Published
2026-02-24
DOI
https://doi.org/10.1097/inf.0000000000005195
Primary Topic
HIV-related health complications and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Body Composition Changes in Children Living With HIV Initiated on Dolutegravir or Protease Inhibitors in the CHAPAS-4 Trial

Grace Ndeezi, Spencer Byaruhanga, Ann Sarah Walker, Esther Nambi et al.
The Pediatric Infectious Disease Journal
HIV-related health complications and treatments
article

Body Composition Changes in Children Living With HIV Initiated on Dolutegravir or Protease Inhibitors in the CHAPAS-4 Trial

Grace Ndeezi, Spencer Byaruhanga, Ann Sarah Walker, Esther Nambi, Alex J. Szubert, Abbas Lugemwa, Victor Musiime, Mary Nyathi, Diana M. Gibb, Philippa Musoke
article en

Abstract

DTG and ATV/r were associated with greater gains in fat-free mass and muscle mass than LPV/r, while DRV/r, TAF and prior nevirapine exposure were associated with fat mass accrual. Fat gain may initially reflect return to health but sustained increases may have metabolic implications. These findings suggest the need to monitor fat compartments with long-term exposure.

The Pediatric Infectious Disease Journal
University of Zimbabwe (ZW), Mpilo Central Hospital (ZW), University of Zambia (ZM), MUJHU Research Collaboration (UG), Joint Clinical Research Centre (UG), University College London (GB), Makerere University (UG), Medical Research Council (GB)
Good health and well-being
Openalex Percentile: Top 48%
HIV-related health complications and treatments
DOISourceOpenAlex
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