Impaired interhemispheric inhibition in isolated REM sleep Behavior Disorder: first exploratory Transcranial Magnetic Stimulation-based evidence
Prolonged iSP duration and the finding on cSP latency in iRBD strengthen the notion of GABAergic dysfunction extending to transcallosal pathways. Such alterations might contribute to dream-enactment behaviors and subtle cognitive deficits observed. These exploratory findings open new avenues for understanding RBD pathophysiology and may support the development of targeted "pharmaco-TMS" strategies in prodromal synucleinopathies.
Authors
- A. Galeano
- Mariagiovanna Cantone (ORCID: https://orcid.org/0000-0002-9072-4971)
- Angelo Garifoli
- Francesca Ginatempo (ORCID: https://orcid.org/0000-0002-8424-6037)
- Maria P. Mogavero (ORCID: https://orcid.org/0000-0001-6662-2281)
- Franca Deriu
- Angelica Quercia (ORCID: https://orcid.org/0000-0002-7121-0692)
- Mariangela Tripodi (ORCID: https://orcid.org/0000-0002-5703-299X)
- Pietro Marano (ORCID: https://orcid.org/0000-0002-6104-6040)
- Patrizia Congiu (ORCID: https://orcid.org/0000-0002-7680-8722)
- Manuela Pennisi (ORCID: https://orcid.org/0000-0003-0776-1411)
- Claudio Liguori (ORCID: https://orcid.org/0000-0003-2845-1332)
- Manuela Morreale
- F. Cosentino (ORCID: https://orcid.org/0000-0003-1296-9321)
- B. Lanuzza
- A. Palmigiano
- W. Paulus
- G. Pastorello
- R. Bella
- Monica Puligheddu
- Elena Antelmi
- Raffaele Ferri
- Giuseppe Lanza
- Rossella Toscano
- Michela Figorilli
- Giuseppe Toscano
- Francesco Sarritzu
Institutions
- University of Rome Tor Vergata (IT)
- University of Verona (IT)
- University of Sassari (IT)
- University of Cagliari (IT)
- Sleep Research Society (US)
- University of Catania (IT)
- Oasi Maria SS (IT)
- Surgical Specialties (Canada) (CA)
- Azienda Ospedaliero Universitaria di Sassari (IT)
- Azienda Ospedaliero-Universitaria Cagliari (IT)
- Policlinico Universitario di Catania (IT)
- I.R.C.C.S. Oasi Maria SS (IT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- SLEEP
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1093/sleep/zsag050
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00